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Atlas of Human Brain Blood Vessels Highlights Changes in Alzheimer's Disease

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Researchers have provided the most unbiased and comprehensive molecular atlas of human brain vasculature in Alzheimer’s disease at single-cell resolution and across multiple brain regions.

Credit: Alex Shipps/MIT CSAIL via Midjourney

Scientists at the Massachusetts Institute of Technology (MIT), Harvard University, and Chicago’s Rush Alzheimer's Disease Center created a molecular atlas of human brain blood vessels to highlight Alzheimer's disease (AD)-related changes across six regions.

The atlas encompassed 428 donors, including 220 receiving AD diagnoses and 208 controls.

The researchers defined more than 22,514 vascular cells from the six brain regions, gauging the expression of thousands of genes for each cell.

The subsequent datasets exposed gene expression changes across different regions, markedly differentiating persons with and without AD.

Said Manolis Kellis of MIT’s Computer Science and Artificial Intelligence Laboratory, the work provides “a map to guide biological and therapeutic investigations earlier in disease progression.”

From MIT News
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Abstracts Copyright © 2023 SmithBucklin, Washington, D.C., USA


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