The Telomere-to-Telomere consortium led by the U.S. National Human Genome Research Institute's Arang Rhie has completed sequencing the human genome by adding the fully mapped Y chromosome.
The consortium used sophisticated sequencing methods and new bioinformatic algorithms to weave together lengthy DNA segments that have long prevented the Y chromosome's readability.
The researchers filled in more than 30 million missing "letters" in the DNA sequence to chart the Y chromosome completely, covering 62,460,029 base pairs.
They also remedied errors in previously sequenced segments and uncovered 41 new protein-coding genes.
Johns Hopkins University's Dylan Taylor said this accomplishment will allow researchers to "identify and explore numerous genetic variations that could be impacting human traits and disease in a way that we weren't able to do before."
View Full Article
Abstracts Copyright © 2023 SmithBucklin, Washington, D.C., USA
No entries found