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New Probe Promises to Reveal Brain's Mysteries

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New cures for neurological disease and a better understanding of how the brain works are among the dozens of potential applications awaiting a new neurological probing platform developed by European scientists. Parkinson's, obsessive compulsive disorder (OCD), Alzheimer's and schizophrenia are among the brain conditions that could also benefit.

The NeuroProbes platform is a modular, three-dimensional probing system that can sense and stimulate individual brain cells both electrically and chemically, and it opens the door to dozens of new research programs, and even promises to refine work currently underway.

The platform will not only play a role in understanding brain disorders and disease, it will also provide a host of new ways to study normal brain behavior and explain why and how we act the way we do.

Creating New Paradigms

The potential applications of the research are vast; from curing disease to creating new paradigms for understanding the massive parallel processing that takes place within the brain when we perform ordinary, day-to-day tasks.

One of the key roles for the new platform will be pre-operative diagnostics prior to brain surgery for a variety of conditions. "It is known that similar probes have been used for decades to discover the focus of an epileptic seizure, for example," says Herc Neves, scientist at Belgium's IMEC and coordinator of the NeuroProbes project.

"You have a patient that is about to be operated on, and you want to remove as little tissue as possible. By pinpointing where the seizure is generated, you remove only that tissue. It means safer, less invasive surgery," he says.

Many neurosurgeons will use the probes in this manner, but one of the most important applications will be fundamental brain research, typically using animal models. A typical neurology processes uses probes and functional magnetic resonance imaging (fMRI) to test certain behaviors in animals. Then researchers use that information and fMRI to deduce behavior in humans.

NeuroProbes modular platform could have dozens of application. Take mirror neurons, research pioneered by Professor Giacomo Rizzolatti from University of Parma, a partner in the NeuroProbes consortium. Mirror neurons fire when a person acts consciously, such as grasping an object, or if the subject watches somebody else perform the action. The same neurons fire when you dream about the action.

"It has enormous implications for learning, and it is exactly the type of research that [the project's] probes were designed to facilitate," explains Neves. "That, in turn, has implications for people with cognitive disabilities. So, for example, we could understand a lot more about autism if we could understand these mirror neurons better."

This is only one little aspect of what is not yet known about the human brain, Neves says, but it is where NeuroProbes' work really begins to shine.

Probing the Brain's Interplay

Behavioral disorders like schizophrenia and OCD are other examples. They are related to the prefrontal cortex, and there is a possible interplay between different sub-areas, or sectors of the pre-frontal cortex. Right now, neurologists do not know how these different areas are related to each other. It is something that you cannot study with fMRI.

"But, experimentally, you can [study this] by using NeuroProbes to chemically switch off one area and look at how it affects the others. You temporarily switch them off chemically, but when the effect of the drug wears [off] the brain has the same function as before," Neves says.

Of course, once a particular mechanism is understood, NeuroProbes can be used in surgical operations to deal with the problem. For example, it can guide a surgeon to the focus of epileptic seizures in a particular patient in order to render it inactive. So there is a lot of exchange between research and medicine.

Electrical sensing can be used to track a single cell actively or a group of cells. "We know quite well what areas of the brain are implicated in this or that activity. We even know what relatively small regions of the brain are involved in learning and cognitive tasks, for example. But the bridge between that regional activity and activity at the cellular level is still incomplete. That's where it is important to have this kind of probing platform," Neves says.

More Data for Implants

Cochlear implants was another internal interest among NeuroProbes' consortium members. These implants are among the most successful ever produced, working extremely well in thousands of cases, enormously improving the quality of life for those who use them.

But they only work where all the neural structures are intact. In many cases, those structures are not intact, and while researchers understand very well what is happening in the ear, that knowledge becomes much more uncertain as the nerve approaches the cortex, and things become more complicated.

Neves believes that the NeuroProbes platform could shed enormous light on the hearing process closer to the cortex, perhaps making it possible to directly stimulate the auditory cortex, for those cases where the patient's nerve is damaged. Visual prosthesis, as well, could benefit from the high-resolution data provided by NeuroProbes.

Chemical sensing and actuation, too, offer very promising research avenues, and a team in Cambridge is using the chemical probes to explore the mechanism of drug addiction. NeuroProbes chemical sensing probes work with both choline and glutamate, two of the most important and active chemicals in the brain, so the scope of potential work is enormous.

The NeuroProbes concept has proven quite popular, generating some excitement among researchers and industrial players. "Almost every meeting we go to, we are approached by neuroscientists asking us where they can get their hands on these probes," Neves says. "They tell us they need the probes yesterday!"

A start-up company is planned to fabricate these probes and keep up with the huge demand among neurology researchers worldwide.

"There is enough demand to keep several companies going, and we have specific structures in place, at IMEC and among many of our partners, to create spin-off companies for our research. IMEC will certainly be providing support and we are always interested in talking to potential investors," Neves says.

The team has also applied for further funding under the EU's Seventh Framework Program for research. That project would take the research much further by looking at deeper brain regions. But the work already completed by the researchers will continue to have an impact for many years to come, revealing the secret life of the brain.

The NeuroProbes project received funding under the ICT strand of the EU's Sixth Framework Program for research.

From ICT Results


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